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Related Experiment Videos

Lymphedema-induced lymphangiosarcoma

A J Janse1, F van Coevorden, H Peterse

  • 1Department of Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek ziekenhuis, Amsterdam.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|April 1, 1995
PubMed
Summary
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This study presents eight cases of chronic lymphedema-related lymphangiosarcoma. Most cases had rapid, fatal progression, but one showed slow, asymptomatic development.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Lymphangiosarcoma is a rare malignancy that can arise secondary to chronic lymphedema.
  • Stewart-Treves syndrome describes lymphangiosarcoma developing in the setting of chronic lymphedema, often post-mastectomy radiation therapy.

Purpose of the Study:

  • To present a series of patients with chronic lymphedema-related lymphangiosarcoma.
  • To discuss the clinical presentation, etiology, and treatment options for this rare condition.

Main Methods:

  • Retrospective case series of eight patients diagnosed with lymphangiosarcoma.
  • Review of clinical data, treatment, and outcomes.

Main Results:

  • Seven out of eight patients experienced rapid disease progression and fatal outcomes, consistent with literature reports.

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  • One patient presented with an asymptomatic, slow-progressing lymphangiosarcoma on the chest wall, axilla, and arm following mastectomy and radiotherapy for lymphedema.

    • Conclusions:

    • Lymphangiosarcoma associated with chronic lymphedema typically follows an aggressive course.
    • A rare, slow-progressing variant may occur, highlighting the importance of vigilant monitoring in patients with chronic lymphedema.