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The beta-2 adrenergic receptor and its agonists

W K Dolen1

  • 1Department of Pediatrics, Medical College of Georgia, Augusta 30912.

Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|November 1, 1994
PubMed
Summary

Beta 2 adrenoceptor agonists are effective for asthma, but desensitization can occur. Corticosteroids prevent and reverse this, while long-acting beta agonists require careful consideration alongside anti-inflammatory asthma management.

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Area of Science:

  • Pharmacology
  • Molecular Biology
  • Immunology

Background:

  • The beta 2 adrenoceptor's structure and function are elucidated.
  • Agonist stimulation leads to known clinical effects.
  • Receptor desensitization is a common phenomenon.

Purpose of the Study:

  • To review the role of beta 2 adrenoceptor agonists in asthma therapy.
  • To discuss receptor desensitization and its modulation.
  • To examine the clinical relevance of beta agonist use in asthma.

Main Methods:

  • Literature review of beta 2 adrenoceptor function and asthma pharmacotherapy.
  • Analysis of mechanisms underlying receptor desensitization.
  • Evaluation of clinical data on beta agonist efficacy and safety.

Main Results:

  • Beta 2 adrenoceptor agonists are effective in asthma treatment.
  • Corticosteroids can prevent and reverse agonist-induced desensitization.
  • Long-acting beta agonists offer prolonged bronchodilation.
  • Potential links between beta agonist use and asthma morbidity/mortality require scrutiny.

Conclusions:

  • Beta 2 agonists are valuable asthma medications, but desensitization is a concern.
  • Corticosteroids are crucial for managing desensitization.
  • Chronic asthma therapy necessitates anti-inflammatory strategies, including allergen avoidance and immunotherapy when indicated.
  • Careful consideration of beta agonist use alongside comprehensive asthma management is essential.

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