Related Experiment Videos
A hox/hom homeobox gene in sponges
B M Degnan1, S M Degnan, A Giusti
1Marine Biotechnology Center, University of California, Santa Barbara 93106, USA.
Abstract:
The hox/hom homeobox genes code for DNA-binding proteins that confer positional information during animal development; these genes have been found in a wide range of triploblasts and in cnidarians. We report here the identification of a hox/hom gene and two other homeobox genes in the genomes of sponges. This finding extends the detection of hox/hom genes to the lowest metazoan phylum and suggests a monophyletic origin of the kingdom Animalia. Because, in culture, sponge cells quickly reaggregate, differentiate and construct tissue after disaggregation, they can provide a useful model system for characterization of the basic roles of homeobox genes in the control of cellular differentiation.