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Related Experiment Videos

Calciotropic hormones and ageing

J L Wémeau1

  • 1Service de Clinique Médicale et d'Endocrinologie, USNA-CHRU, Lille, France.

Hormone Research
|January 1, 1995
PubMed
Summary

Calcium absorption declines in older adults due to reduced dietary intake, less sun exposure, and decreased vitamin D production. Ageing also impacts hormones crucial for bone health, affecting calcium availability and bone remodelling.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Nutritional Science

Background:

  • Ageing leads to reduced calcium availability through decreased dietary intake and impaired vitamin D metabolism.
  • Diminished solar exposure and skin's reduced provitamin D production further compromise calcium balance in the elderly.
  • Age-related changes in calcitriol synthesis and activity decrease intestinal calcium absorption.

Purpose of the Study:

  • To investigate the multifactorial decline in calcium availability and its impact on bone health in the elderly.
  • To explore the hormonal changes associated with ageing that affect calcium homeostasis and bone remodelling.
  • To assess the potential role of growth hormone (GH) therapy in managing bone mass in older adults.

Main Methods:

  • Review of physiological changes in calcium metabolism with ageing.
  • Analysis of hormonal alterations including parathormone, calcitonin, growth hormone (GH), and insulin-like growth factor I.
  • Examination of factors influencing vitamin D and calcitriol levels and their effects on calcium absorption.

Main Results:

  • Elderly individuals exhibit reduced calcium absorption due to decreased dietary intake, lower vitamin D levels, and impaired synthesis/activity of calcitriol.
  • Ageing is associated with increased parathormone, decreased calcitonin secretion possibly linked to sex steroid and calcitriol loss.
  • Growth hormone (GH) and insulin-like growth factor I concentrations decrease with age, with the efficacy of GH therapy on bone mass remaining under investigation.

Conclusions:

  • Ageing significantly impairs calcium homeostasis through multiple physiological pathways, including reduced intake, synthesis, and absorption.
  • Hormonal shifts in ageing, such as decreased calcitonin and altered parathormone levels, contribute to bone remodelling changes.
  • Further research is needed to confirm the effectiveness of growth hormone (GH) therapy for improving bone mass in the elderly population.

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