Noninvasive testing in the diagnosis and management of unstable angina

Patients presenting with a clinical diagnosis of unstable angina comprise a heterogenous population and a wide spectrum of patients with varying degrees of underlying coronary artery disease, severity and prognosis are categorized in this syndrome. A very small number of patients with unstable angina who are refractory to adequate in-hospital medical therapy should undergo urgent coronary angiography and, if suitable, revascularization. The vast majority of patients do, however, stabilize on medical therapy and an invasive approach, such as a coronary angiography should not be performed routinely to all of these patients. Early recognition of clinical and non-invasive test variables indicating an adverse outcome is of paramount importance in unstable angina. This review focuses on the importance of baseline clinical markers and the usefulness of a non-invasive approach with exercise testing, myocardial perfusion imaging, stress echocardiography, and Holter monitoring in the diagnosis, risk stratification, and management of patients with unstable angina.