Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Host primary olfactory axons make synaptic contacts in a transplanted olfactory bulb

B L Goheen1, J N Kott, N L Anderson

  • 1Department of Neurological Surgery, University of Washington, Seattle 98195, USA.

The Journal of Comparative Neurology
|February 6, 1995
PubMed
Summary

Host olfactory neurons successfully form synaptic connections within transplanted olfactory bulbs. This study confirms the structural integration and plasticity of olfactory bulb transplants in rats, restoring neural pathways.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preferences for tongue swab versus sputum collection for TB testing: a multi-country survey.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2026
Same author

Changes in fundus by optical coherence tomography in patients with chronic obstructive pulmonary disease: A systematic review.

The Medical journal of Malaysia·2025
Same author

Erratum: Centrality-Dependent Modification of Jet-Production Rates in Deuteron-Gold Collisions at sqrt[s_{NN}]=200  GeV [Phys. Rev. Lett. 116, 122301 (2016)].

Physical review letters·2025
Same author

Risk of cardiovascular diseases and gastrointestinal bleeding is comparable between celecoxib and non-selective non-steroidal anti-inflammatory drugs in patients with ankylosing spondylitis: a nationwide retrospective cohort study.

Scandinavian journal of rheumatology·2025
Same author

Efficacy, safety, and pharmacokinetics of eribulin as monotherapy or in combination with irinotecan for patients with pediatric rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, or Ewing sarcoma.

ESMO open·2025
Same author

First Measurement of Deeply Virtual Compton Scattering on the Neutron with Detection of the Active Neutron.

Physical review letters·2024

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Olfactory System Research

Background:

  • Previous studies indicated functional recovery after olfactory bulb transplantation.
  • Light microscopy suggested host neuron integration into transplanted tissue.

Purpose of the Study:

  • To ultrastructurally confirm synaptic reestablishment between host olfactory neurons and donor olfactory bulb tissue.
  • To investigate the plasticity of transplanted olfactory bulbs at the synaptic level.

Main Methods:

  • Utilized immunoelectron microscopy with an olfactory marker protein antibody and gold-conjugated secondary antibody.
  • Employed Lowicryl K4M resin for antigen preservation during ultrathin sectioning.
  • Examined olfactory bulb transplants in mature rats that received neonatal transplants.

Related Experiment Videos

Main Results:

  • Confirmed unmistakable synaptic contacts between labeled host olfactory neuron axons and unlabeled donor processes within glomerulus-like structures.
  • Observed normal synaptic contacts within the transplanted olfactory bulb's neuropil.
  • Demonstrated significant plasticity in the transplanted olfactory bulb, enabling formation of diverse synaptic connections.

Conclusions:

  • Transplanted olfactory bulbs achieve ultrastructural integration with host neural circuitry.
  • Host olfactory neurons form functional synaptic connections with transplanted tissue, supporting neural plasticity.
  • This provides a structural basis for the observed functional recovery of olfaction after transplantation.