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Porokeratosis and Crohn's disease
C A Morton1, D Shuttleworth, W S Douglas
1Department of Dermatology, Monklands District General Hospital, Airdrie, Scotland.
Journal of the American Academy of Dermatology
|May 1, 1995
Summary
This study details three Crohn's disease patients who developed porokeratosis, a skin condition. Skin lesions appeared during active bowel disease flares, suggesting a potential link between the conditions.
Area of Science:
- Dermatology
- Gastroenterology
- Internal Medicine
Background:
- Crohn's disease is a chronic inflammatory bowel disease.
- Porokeratosis is a group of chronic disorders of keratinization affecting the skin.
Observation:
- Three patients with Crohn's disease developed porokeratosis.
- Two patients presented with disseminated superficial actinic porokeratosis (DSAP).
- One patient developed DSAP during a Crohn's disease exacerbation; another developed it during their first severe Crohn's flare.
Findings:
- Congenital linear porokeratosis was observed in one patient.
- Crohn's disease was limited to the colon in all three cases.
- A family history of porokeratosis existed in one patient, but not of Crohn's disease.
Implications:
- This case series highlights a potential association between Crohn's disease and porokeratosis.
- Further research is warranted to explore the pathomechanisms linking these conditions.
- Clinicians should be aware of this potential comorbidity in patients with Crohn's disease.