Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus

Associations of multiple dermatofibromas with autoimmune disorders, altered immunity, or both have been described. We report the case of a 33-year-old black woman with HIV infection and an 11-year history of systemic lupus erythematosus in whom 15 dermatofibromas developed while she was receiving systemic corticosteroid therapy. Including our patient, multiple dermatofibromas have been described in 15 patients with an autoimmune disease, altered immunity, or both. All 12 of the women with multiple dermatofibromas had systemic lupus erythematosus.