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Related Experiment Videos

Hemoglobin levels during twin vs. singleton pregnancies. Parity makes the difference

I Blickstein1, R Goldschmit, S Lurie

  • 1Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.

The Journal of Reproductive Medicine
|January 1, 1995
PubMed
Summary

Lower hemoglobin levels are more common in twin pregnancies, especially in multiparous women during the first two trimesters. Twin pregnancies may require closer hematologic monitoring and iron supplementation.

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Perinatal Medicine

Background:

  • Twin pregnancies are associated with unique physiological changes.
  • Hemoglobin levels during pregnancy are critical indicators of maternal health.
  • Previous research has yielded mixed results regarding hemoglobin levels in twin gestations.

Purpose of the Study:

  • To investigate the hypothesis that lower hemoglobin values occur more frequently in twin gestations compared to singleton gestations.
  • To analyze hemoglobin levels across trimesters in twin versus singleton pregnancies.
  • To identify specific subgroups within twin pregnancies that may be at higher risk for lower hemoglobin.

Main Methods:

  • A retrospective case-control study involving 200 twin and singleton pregnancies matched for parity.

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  • Hemoglobin levels were recorded during each trimester of pregnancy.
  • Statistical comparisons of mean hemoglobin levels and incidence of specific hemoglobin ranges (>11, 9-11, <9 g/dL) were performed.

    • Main Results:

    • Significantly lower mean hemoglobin values were observed in twin gestations during the first and second trimesters compared to singleton gestations.
    • These differences were primarily driven by lower hemoglobin levels in multiparous women carrying twins.
    • During the second trimester, twin pregnancies showed a lower incidence of hemoglobin >11 g/dL and a higher incidence of values between 9-11 g/dL.

    Conclusions:

    • Lower hemoglobin levels in twin gestations are significantly associated with multiparity and are most pronounced in the first and second trimesters.
    • Twin pregnancies, particularly those in multiparous women, may benefit from closer hematologic monitoring.
    • Consideration for monitored iron supplementation in this specific subgroup of twin pregnancies is suggested.