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Reliability enhancement and estimation in multisite clinical trials

F K Del Boca1, T F Babor, B McRee

  • 1Department of Psychiatry, University of Connecticut Health Center, Farmington 06030-1410.

Journal of Studies on Alcohol. Supplement
|December 1, 1994
PubMed
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Enhancing measurement reliability in multisite clinical trials, especially in addictions research, is crucial. This study details methods to improve and assess the consistency of self-report data and psychiatric diagnoses.

Area of Science:

  • Clinical Psychology
  • Psychiatric Epidemiology
  • Addictions Research

Background:

  • Clinical trials frequently use self-report data, necessitating evaluation of measurement error.
  • Reliability of data is paramount for valid outcomes in multisite research.

Purpose of the Study:

  • To present methods for enhancing and assessing measurement reliability in multisite clinical research.
  • To identify sources of inconsistency in data collection for psychiatric diagnoses and verbal self-reports.

Main Methods:

  • Overview of reliability evaluation approaches for psychiatric diagnoses and self-reports.
  • Description of an interview process model to identify data collection inconsistencies.
  • Proposal of a research design for evaluating reliability in multisite investigations.

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Main Results:

  • Identified major sources of inconsistency in the interview and data collection process.
  • Recommended staff selection, training, and quality assurance procedures.
  • Proposed a suitable research design for multisite reliability assessment.

Conclusions:

  • Implementing recommended procedures can enhance the reliability of interview assessments.
  • Systematic approaches are vital for minimizing random and systematic error in clinical trial data.
  • Reliable measurement is essential for the validity of findings in multisite addictions research.