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Immunosuppressive acidic protein in intraocular fluids
Y Takeda1, K Yamaguchi, M Tamai
1Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
Japanese Journal of Ophthalmology
|January 1, 1994
Summary
Immunosuppressive acidic protein (IAP) levels are elevated in ocular diseases like uveitis and diabetic retinopathy, suggesting intraocular production and a role in modulating eye inflammation.
Area of Science:
- Ophthalmology
- Immunology
- Biochemistry
Background:
- Immunosuppressive acidic protein (IAP) is a known immunosuppressor.
- Its role in intraocular diseases is not well understood.
Purpose of the Study:
- To measure IAP levels in ocular fluids of patients with various eye conditions.
- To investigate the potential intraocular synthesis and role of IAP in ocular inflammation.
Main Methods:
- Vitreous and aqueous humor samples were collected from patients undergoing surgery for uveitis, diabetic retinopathy, intraocular tumors, and cataracts.
- IAP levels were quantified using single radial immunodiffusion assay.
- Intraocular IAP synthesis was assessed by calculating the percentage of IAP in uveitis patients.
Main Results:
- Significantly higher vitreous IAP levels were observed in patients with uveitis, tumors, and diabetic retinopathy compared to premacular fibrosis.
- Uveitis patients showed a higher percentage of vitreous IAP, indicating intraocular production.
- Aqueous IAP levels were markedly elevated in uveitis patients compared to senile cataract patients.
- IAP levels correlated with disease activity in a patient with Behçet's disease.
Conclusions:
- The eye can produce immunosuppressive acidic protein (IAP).
- Elevated IAP levels in various ocular diseases suggest its involvement in intraocular inflammatory processes.
- IAP may play a role in modulating the immune response within the eye.