Fluorescein angiographic features of neovascular maculopathy in angioid streaks

Among the 46 eyes of 23 patients diagnosed with angioid streaks, macular complications (subretinal neovascularization) were found in 20 eyes of 11 patients (43.5%): the 14 eyes of 7 males, and 6 eyes of 4 females. Of these patients, 81.8% were in their fifties to sixties. The patients with and without macular complications did not differ in the incidence of pseudoxanthoma elasticum and other ocular findings, including peau d'orange and salmon spots. In 17 eyes of 10 patients (85%) with macular complications, fluorescein angiography demonstrated multiple small, round, hypofluorescent dots in the area temporal to the macula and around the optic disc. The extent of this lesion varied from simple hypofluorescent dots to dots each surrounded by a hyperfluorescent area. These changes could be detected not by ophthalmoscopic fundus examination but only by fluorescein angiography.