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Related Experiment Video

Updated: Jul 23, 2026

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

Published on: September 23, 2011

Jumping translocations in leukemia

V Najfeld¹, B Hauschildt, A Scalise

¹Tumor Cytogenetics Laboratory, Polly Annenberg Levee Hematology Center, New York, NY, USA.

|April 1, 1995

Summary

Jumping translocations, rare in leukemia, were observed in three patients. These chromosomal rearrangements may indicate a poor prognosis in leukemia patients.

Area of Science:

Hematology
Cytogenetics
Cancer Biology

Background:

Jumping translocations are rare chromosomal abnormalities.
Their role in leukemia pathogenesis is not well understood.

Observation:

Three leukemia patients presented with multiple related clones.
These clones resulted from unbalanced jumping translocations involving 1q and 7q.
Translocations occurred to chromosomes 1, 8, 15, 21, and 22.

Findings:

Jumping translocations in leukemia appear to be non-random.
These rearrangements may serve as adverse prognostic markers.

Implications:

The findings suggest jumping translocations are significant in leukemia.

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Further research into the origin and mechanism of these translocations is warranted.

Telomeric ends of chromosomes might be involved in stabilizing these rearrangements in malignant cells.