Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atrial natriuretic factor in gynecologic malignancy

J V Fiorica1, L Graham, P S Rao

  • 1Department of Obstetrics and Gynecology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, USA.

Obstetrics and Gynecology
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epilepsy and Pregnancy: For healthy pregnancies and happy outcomes. Suggestions for service improvements from the Multispecialty UK Epilepsy Mortality Group.

Seizure·2017
Same author

Co-circulation of four types of infectious bronchitis virus (793/B, 624/I, B1648 and Massachusetts).

Avian pathology : journal of the W.V.P.A·2016
Same author

Longitudinal field studies of infectious bronchitis virus and avian pneumovirus in broilers using type-specific polymerase chain reactions.

Avian pathology : journal of the W.V.P.A·2016
Same author

Overview of a chemoresponse assay in ovarian cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2014
Same author

Tumoricidal function against human cervical-cancer cells in human peritoneal mesothelial cells - contribution of tumor-necrosis-factor-alpha.

International journal of oncology·2011
Same author

Facial reconstruction: soft tissue thickness values for South African black females.

Forensic science international·2011

Plasma atrial natriuretic factor (ANF) levels are elevated in women with gynecologic malignancy compared to healthy individuals. Chemotherapy does not appear to influence these elevated ANF levels.

Area of Science:

  • Endocrinology
  • Oncology
  • Gynecology

Background:

  • Atrial natriuretic factor (ANF) is a hormone involved in cardiovascular regulation.
  • Elevated ANF levels have been observed in various disease states, but their role in gynecologic malignancies is not well-defined.

Purpose of the Study:

  • To investigate plasma ANF levels in patients with gynecologic malignancy.
  • To compare these levels with those in healthy women.
  • To determine if chemotherapy influences ANF levels in these patients.

Main Methods:

  • Plasma ANF levels were measured in three groups: healthy nonpregnant women (n=25), patients with gynecologic malignancy undergoing chemotherapy (n=32), and patients with gynecologic malignancy before chemotherapy (n=18).
  • Statistical analysis was performed to compare ANF levels between groups.

Related Experiment Videos

Main Results:

  • Plasma ANF levels were significantly higher in both patient groups (with and without chemotherapy) compared to healthy controls (P < .001).
  • No significant difference in ANF levels was found between patients receiving chemotherapy and those before chemotherapy initiation.
  • ANF levels varied among different types of gynecologic cancer (endometrial, ovarian, cervical) but remained consistent before and after chemotherapy.

Conclusions:

  • Gynecologic malignancy is associated with significantly elevated plasma ANF levels.
  • The elevated ANF levels observed in these patients are not induced by chemotherapy.
  • These findings suggest a potential role for ANF in the pathophysiology of gynecologic cancers.