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Histiocytosis X and pregnancy
L A DiMaggio1, H A Lippes, R V Lee
1Department of Medicine, State University of New York at Buffalo, USA.
Obstetrics and Gynecology
|May 1, 1995
Summary
Pregnancy with Histiocytosis X is rare, but can cause or worsen diabetes insipidus. Treatment with 8-D-arginine vasopressin is safe for the fetus and does not induce premature labor.
Area of Science:
- Reproductive Endocrinology
- Oncology
- Neurology
Background:
- Histiocytosis X is a rare disorder with infrequent association with pregnancy.
- Diabetes insipidus is a known manifestation of Histiocytosis X.
Observation:
- A pregnant patient with Histiocytosis X developed diabetes insipidus at 31 weeks gestation.
- Magnetic resonance imaging revealed a hypothalamic mass.
- Postpartum, the patient developed a spinal cord mass, treated with surgery and radiation therapy.
Findings:
- Histiocytosis X occurring during pregnancy is uncommon.
- Diabetes insipidus may manifest or exacerbate during pregnancy in affected patients.
- Intranasal 8-D-arginine vasopressin treatment showed no adverse effects on the fetus or labor.
Implications:
- Highlights the importance of monitoring for diabetes insipidus in pregnant patients with Histiocytosis X.
- Suggests intranasal 8-D-arginine vasopressin as a safe treatment option during pregnancy.
- Underscores the aggressive nature of advanced Histiocytosis X, even with treatment.
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