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Related Experiment Videos

[Successfully treated Salmonella enteritidis endocarditis]

L Bíró1, M Lengyel, M Koltai

  • 1Belgyogyászat, Szent László Kórház, Budapest, II.

Orvosi Hetilap
|April 9, 1995
PubMed
Summary
This summary is machine-generated.

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A patient with Salmonella endocarditis experienced neurological symptoms and fever. High-dose ciprofloxacin combined with cefuroxime successfully treated the infection and resolved vegetation.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Neurology

Background:

  • A 60-year-old male presented with aphasia and hemiparesis, indicative of a potential neurological event.
  • Initial investigations revealed a parietal hematoma, treated via stereotactic biopsy.
  • The patient also exhibited hyperpyrexia, mitral valve disease, and atrial fibrillation.

Observation:

  • Blood cultures repeatedly identified Salmonella enteritidis.
  • Transesophageal echocardiography confirmed infective endocarditis with vegetation.
  • Initial antibiotic regimens (ampicillin + gentamicin, amoxicillin-clavulanate + amikacin) proved ineffective.

Findings:

  • Ciprofloxacin monotherapy at standard doses reduced toxicosis and hyperpyrexia but fever persisted.
  • A combined regimen of high-dose intravenous and oral ciprofloxacin plus intravenous cefuroxime for 46 days rendered the patient afebrile.

Related Experiment Videos

  • Transesophageal echocardiography showed complete resolution of the vegetation after treatment.

    • Implications:

    • This case highlights the challenges in treating Salmonella endocarditis, particularly in patients with underlying cardiac conditions.
    • The successful use of high-dose ciprofloxacin in combination with cefuroxime suggests a potential therapeutic strategy for refractory cases.
    • Aggressive antibiotic management, even at high doses, can be effective without significant adverse effects.