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[Prolactin and breast cancer]

C Robyn

    Pathologie-Biologie
    |December 1, 1975
    PubMed
    Summary

    Prolactin influences breast tumor growth in animals, with timing affecting cancer incidence. In women, prolactin

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    Area of Science:

    • Endocrinology
    • Oncology
    • Reproductive Biology

    Context:

    • Prolactin's role in breast tumor development is complex and debated.
    • Animal studies show prolactin can promote tumor growth.
    • Human data on prolactin and breast carcinoma incidence is indirect and sometimes conflicting.

    Purpose:

    • To explore the multifaceted influence of prolactin on breast cancer incidence and growth.
    • To reconcile findings from animal models with human epidemiological data.

    Summary:

    • In animals, prolactin generally promotes breast tumor growth, but its effect on incidence depends on the timing relative to carcinogen exposure.
    • In women, serum prolactin levels in breast cancer patients are similar to controls.
    • Surgical interventions like hysterectomy and ovariectomy, which lower prolactin levels, are associated with remission in generalized carcinoma and may reduce breast cancer incidence.

    Impact:

    • Understanding prolactin's role can inform breast cancer prevention and treatment strategies.
    • Highlights the need for further research into the hormonal regulation of breast carcinogenesis.
    • Suggests potential protective effects of pregnancy-related hormonal changes against breast cancer etiology.

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