Physical and chemical properties of normal and haemophilic factor VIII

This review summarizes the physical and chemical properties of normal factor VIII (antihaemophilic factor). Special attention is given to the different subunits of this molecule, obtained after dissociation by beta-mercaptoethanol, high or low ionic strength. Present points of controversy are outlined. A description is given of the role of factor VIII in coagulation, as it is presently understood. The studies of the physical and chemical properties of haemophilic factor VIII also are reviewed; the molecular defect of haemophilic factor VIII remains to be identified.