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[Clinical experiences with a 6% hydroxyethyl starch 40000 solution; metabolic parameters and tolerance]
Infusionstherapie Und Klinische Ernahrung
|April 1, 1978
Summary
A 6% hydroxyethyl starch (HES) solution effectively stabilized circulation in 779 patients undergoing surgery. This volume expander demonstrated good tolerance and circulation effectiveness, with minimal side effects observed.
Area of Science:
- Pharmacology
- Anesthesiology
- Critical Care Medicine
Context:
- Evaluation of a specific hydroxyethyl starch (HES) solution (6%, 40,000 Da, 0.5-0.55 DS) in a large cohort.
- Study conducted across 79 clinics in West Germany under controlled conditions.
- Inclusion of 779 patients treated for hypovolemia with HES 40,000 alone or in combination with other fluids.
Purpose:
- To assess the tolerance and efficacy of 6% HES 40,000 as a volume expander.
- To evaluate the impact of HES 40,000 on circulatory parameters, serum electrolytes, hemoglobin, and hematocrit.
- To determine the effectiveness of HES 40,000 in maintaining stable circulation during and after anesthesia.
Summary:
- 6% HES 40,000 solution was administered to 779 patients for hypovolemia treatment.
- Stable circulation was achieved within 4-6 hours during narcosis and the post-operative phase.
- Parameters evaluated included tolerance, circulation effectiveness, and effects on electrolytes, hemoglobin, and hematocrit.
Impact:
- Demonstrates the utility of HES 40,000 in managing hypovolemia and maintaining hemodynamic stability.
- Provides evidence for the safety and effectiveness of this specific HES formulation in surgical patients.
- Highlights the potential of HES 40,000 as a reliable fluid resuscitation agent in clinical practice.