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[Biliary elimination of metampicillin. Experimental and clinical study (author's transl)]
Abstract:
Under the conditions of the isolated rabbit liver perfusion, metampicillin was found to be excreted at a high rate in the biliary tract : bile contains 46,5% of the administered dose. Hepatic uptake of metampicillin seems to be early and marked. In man, the biliary elimination of this antibiotic varies according to the route of administration. Only moderate biliary levels of metampicillin were obtained after oral administration ; on the contrary, extremly high biliary concentrations were found when antibiotic was injected intravenously. When parenteraly administered, metampicillin appears to be a particularly suitable penicillin for the treatment of biliary tract infections.
Insights
Metampicillin is highly excreted into bile in rabbits and humans, especially after intravenous administration. This makes it a suitable antibiotic for treating biliary tract infections.
Area of Science:
- Pharmacokinetics and Drug Metabolism
- Hepatobiliary System Research
- Antimicrobial Agent Excretion
Context:
- Investigating the biliary excretion of metampicillin in isolated rabbit liver perfusion models.
- Evaluating human biliary concentrations of metampicillin based on administration route.
- Assessing the efficacy of metampicillin for biliary tract infections.
Purpose:
- To quantify the biliary excretion rate of metampicillin.
- To compare biliary metampicillin levels after oral versus intravenous administration in humans.
- To determine the suitability of metampicillin for treating biliary tract infections.
Summary:
- Metampicillin exhibits high biliary excretion in rabbits, with 46.5% of the dose found in bile.
- Human studies show moderate biliary levels after oral administration but extremely high levels after intravenous injection.
- Hepatic uptake of metampicillin is rapid and significant.
Impact:
- Metampicillin's pharmacokinetic profile supports its use in treating biliary tract infections.
- Intravenous administration leads to optimal biliary concentrations for therapeutic effect.
- Findings inform antibiotic selection for hepatobiliary infections.