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Related Experiment Videos

Expression of basic fibroblast growth factor in thyroid disorders

K Shingu1, A Sugenoya, N Itoh

  • 1Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

World Journal of Surgery
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

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Basic fibroblast growth factor (bFGF) is more prevalent in malignant thyroid tumors, correlating with increased malignancy and lymph node metastasis. A high-molecular-weight form of bFGF may significantly impact tumor growth.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Basic fibroblast growth factor (bFGF) is implicated in various cellular processes.
  • Its role in human thyroid neoplasms requires further clarification.

Purpose of the Study:

  • To investigate the biologic significance of bFGF in human thyroid neoplasms.
  • To correlate bFGF expression with tumor malignancy and metastatic potential.

Main Methods:

  • Immunohistochemical analysis (avidin-biotin-peroxidase complex) of bFGF in 71 malignant tumors and 23 benign/normal thyroid tissues.
  • Western blot analysis of bFGF molecular weight forms in malignant thyroid tumor eluates.

Main Results:

  • bFGF was frequently detected in the cytoplasm of malignant thyroid tumors, especially anaplastic carcinomas, compared to benign tissues.

Related Experiment Videos

  • Positive bFGF staining in papillary carcinoma correlated significantly with nodal metastasis (UICC TNM classification).
  • Western blot identified 18 kDa and 33 kDa bFGF forms; the 33 kDa form was unique to anaplastic carcinoma.

    • Conclusions:

    • bFGF expression correlates with the degree of malignancy in human thyroid neoplasms.
    • bFGF may promote lymph node metastasis.
    • The high-molecular-weight bFGF form might intensely influence tumor growth.