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Related Experiment Videos

Lactate metabolism and hypocarbic hyperventilation. An experimental study in piglets

T Karlsson1, E L Stjernström, H Stjernström

  • 1Department of Anaesthesiology and Intensive care, Uppsala University Hospital, Sweden.

Acta Anaesthesiologica Scandinavica
|January 1, 1995
PubMed
Summary

Hyperventilation increases blood lactate, but not due to muscle release. Instead, the liver (splanchic region) alters lactate turnover during hyperventilation, leading to higher blood lactate levels.

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Area of Science:

  • Physiology
  • Biochemistry

Background:

  • Hyperventilation is known to elevate blood lactate levels.
  • The precise mechanisms, whether peripheral release or hepatic uptake, remain unclear.

Purpose of the Study:

  • To investigate the source of increased blood lactate during hyperventilation.
  • To differentiate between peripheral lactate release and hepatic lactate uptake.

Main Methods:

  • Studied piglets under controlled normoventilation and hyperventilation.
  • Measured blood lactate in femoral and hepatic veins.
  • Assessed hind limb and splanchnic blood flow.
  • Analyzed muscle biopsies for lactate and related metabolites.

Main Results:

  • Arterial lactate concentration was significantly higher in hyperventilated piglets.

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  • Lactate release from hind limb muscles and muscle lactate content remained unchanged.
  • Skeletal muscle metabolic profiles were similar between groups.
  • The splanchnic region shifted from no lactate exchange to lactate release during hyperventilation.

    • Conclusions:

    • Increased blood lactate during hypocarbic hyperventilation in piglets is not due to increased peripheral skeletal muscle release.
    • Altered splanchnic (hepatic) turnover of lactate likely contributes to elevated blood lactate levels during hyperventilation.