Related Experiment Videos
Histamine concentrations and hemodynamic responses after remifentanil
P S Sebel1, J F Hoke, C Westmoreland
1Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Anesthesia and Analgesia
|May 1, 1995
Summary
This study examined hemodynamic responses to remifentanil, a potent opioid analgesic. Remifentanil administration significantly reduced blood pressure and heart rate without altering histamine levels.
Area of Science:
- Anesthesiology
- Pharmacology
- Cardiovascular Physiology
Background:
- Remifentanil is a novel, potent opioid analgesic.
- It is characterized by rapid esterase metabolism.
- Understanding its hemodynamic effects is crucial for clinical application.
Purpose of the Study:
- To investigate the hemodynamic responses to escalating doses of remifentanil.
- To assess the impact of remifentanil bolus administration on blood pressure and heart rate.
- To evaluate potential histamine release associated with remifentanil.
Main Methods:
- General anesthesia was induced with endotracheal intubation.
- Patients received escalating doses of remifentanil (2-30 µg/kg) intravenously over 1 minute.
- Hemodynamic parameters (blood pressure, heart rate) and plasma histamine levels were monitored.
Main Results:
- Remifentanil administration resulted in a significant decrease in systolic blood pressure (from 134 ± 18 to 91 ± 16 mm Hg).
- Heart rate also decreased significantly (from 99 ± 20 to 69 ± 21 bpm).
- No significant alterations in histamine concentration were observed post-administration.
Conclusions:
- Remifentanil causes dose-dependent reductions in blood pressure and heart rate.
- These hemodynamic changes occur without significant histamine release.
- Remifentanil is a potent analgesic with predictable cardiovascular effects during general anesthesia.