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Antibacterial activities of cefprozil compared with those of 13 oral cephems and 3 macrolides
J C Fung-Tomc1, E Huczko, T Stickle
1Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
Abstract:
Thirteen oral cephems (cefprozil, loracarbef, cefaclor, cefuroxime axetil, cefpodoxime proxetil, cefetamet pivoxil, cefixime, cefdinir, cefadroxil, cephradine, cephalexin, cefatrizine, and cefroxadine), the cephalosporin class representative cephalothin, cefazolin, and the macrolides erythromycin, clarithromycin, and azithromycin were compared for their antibacterial activities against 790 recent clinical isolates. These oral agents differed in their spectra and antibacterial potencies against community-acquired pathogens.
Insights
This study compared oral cephalosporins and macrolides against common bacterial infections. Results show significant differences in effectiveness and spectrum of activity for these important antibiotics.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Oral cephalosporins and macrolides are widely prescribed for community-acquired infections.
- Understanding their comparative antibacterial activity is crucial for effective treatment selection.
Purpose of the Study:
- To compare the antibacterial activity of thirteen oral cephalosporins and three macrolides.
- To evaluate their potency against a diverse panel of recent clinical isolates.
Main Methods:
- Antibacterial activity was assessed using 790 recent clinical isolates.
- The study included cefprozil, loracarbef, cefaclor, cefuroxime axetil, cefpodoxime proxetil, cefetamet pivoxil, cefixime, cefdinir, cefadroxil, cephradine, cephalexin, cefatrizine, cefroxadine, cephalothin, cefazolin, erythromycin, clarithromycin, and azithromycin.
Main Results:
- Significant variations in antibacterial spectra were observed among the tested oral agents.
- Differences in antibacterial potency against community-acquired pathogens were also noted.
- Specific cephalosporins and macrolides demonstrated superior activity against certain bacterial types.
Conclusions:
- Oral cephalosporins and macrolides exhibit distinct antibacterial profiles.
- This comparative data aids in optimizing antibiotic selection for community-acquired infections.
- Further research into resistance patterns is warranted.