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Synthesis of phthalimido-desmuramylpeptide analogues as potential immunomodulating agents
U Urleb1, A Krbavcic, M Sollner
1Department of Pharmacy, University of Ljubljana, Slovenia.
Archiv Der Pharmazie
|February 1, 1995
Abstract:
The preparation of immunologically active phthalimido desmuramylpeptide analogues 2e-h, 4c-d, and 7b is described. The N-acetylmuramic acid in the muramyl dipeptide has been replaced by a phthaloylated acyclic moiety such as N-phthaloylated amino acids 1a-c, 2-(2-phthalimidoethoxy)acetic acid 3, or by the carbocyclic rac. trans-2-(2'-phthalimidocyclohexyloxy)acetic acid 6.