Related Experiment Videos
[Acetylation of spironolactone, canrenone and 2-methyl-canrenone]
K Görlitzer1, P Moormann, K Pollow
1Institut für Pharmazeutische Chemie, Technischen Universität Braunschweig.
Archiv Der Pharmazie
|February 1, 1995
Abstract:
Reaction of the title compounds with acetic anhydride and acetyl chloride yields the 3,5-dien-3-yl acetate 2, the isomeric 2,4,6- and 3,5,7-trien-3-yl acetates 3 and 4 as well as the 2,4,6,8(14)-tetraen-3-yl acetate 7. The 2 alpha-methyl-8,14-didehydro-canrenone (9) is obtained by hydrolysis of 7. Binding affinities of 7 and 9 to hormone receptors as well as serum proteins (SHBG, CBG) are investigated. The compounds are inactive.