Interhelical contacts determining the architecture of alpha-helical globular proteins
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Updated: Sep 8, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
I V Grigoriev1, A A Mironov, A B Rakhmaninova
1Department of Mathematical Modelling, Institute for Genetics and Selection of Industrial Microorganisms, Moscow, Russia.
Abstract:
An approach based on a presentation of alpha-helical protein topology as a graph is presented. The approach allows to estimate a role of each interhelical contact in the whole protein topology and to classify the contacts. It is shown that a consideration of only about a half of the whole pool of interhelical contacts exposed in the protein is enough for a determination of protein architecture. Such contacts are called as major and their quantitative characteristics are obtained. Moreover, providing a clear and simple presentation of the protein topology, the approach can be applied for a description of structural domain/subdomain arrangement of alpha-helical proteins and illustration of their folding/denaturation paths.
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