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[Mixed cryoglobulinemia associated with hepatitis C virus]
A De Diego Lorenzo1, R Bañares Cañizares, C González-Asanza
1Servicio de Aparato Digestivo, Hospital General Universitario, Gregorio Marañón, Madrid.
Revista Espanola De Enfermedades Digestivas
|January 1, 1995
Summary
Hepatitis C virus (HCV) infection is linked to mixed cryoglobulinemia, a condition causing vasculitis, joint pain, nerve damage, and kidney issues. This study highlights HCV
Area of Science:
- Hepatology
- Immunology
- Virology
Background:
- Essential mixed cryoglobulinemia is a systemic vasculitis.
- Chronic liver disease is often associated with cryoglobulinemia.
Observation:
- Six patients with chronic liver disease and positive Hepatitis C virus (HCV) markers presented with mixed cryoglobulinemia.
- Acute symptoms included vasculitis, arthralgias, neuropathy, and glomerulonephritis.
Findings:
- HCV RNA and anti-HCV antibodies were detected in serum and cryoprecipitates of all patients.
- Second-generation ELISA and PCR confirmed HCV presence.
Implications:
- Hepatitis C virus plays a significant role in the pathogenesis of mixed cryoglobulinemia.
- Early detection and treatment of HCV may prevent cryoglobulinemia complications.