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Cutaneous B-cell lymphoma with subsequent laryngeal involvement
P Wells1, A Wotherspoon, N G Burnet
1Meyerstein Institute of Clinical Oncology, Middlesex Hospital, London, UK.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|January 1, 1995
Summary
This case report details a rare instance of cutaneous lymphoma relapsing in the larynx. Early laryngeal symptom recognition is crucial for effective treatment of this uncommon non-Hodgkin
Area of Science:
- Oncology
- Dermatology
- Otolaryngology
Background:
- Cutaneous lymphoma is a rare malignancy.
- Laryngeal involvement in lymphoma is uncommon, occurring as primary or multifocal disease.
Observation:
- A case of high-grade cutaneous non-Hodgkin's lymphoma with an isolated laryngeal relapse is presented.
- Histological and PCR analysis confirmed the laryngeal deposit was identical to the primary cutaneous lymphoma.
Findings:
- The patient achieved complete remission of the primary cutaneous lesion with radiotherapy.
- A second complete remission was achieved with chemotherapy for the laryngeal relapse.
Implications:
- This is the first reported case of primary cutaneous lymphoma with subsequent laryngeal involvement.
- Overlooked laryngeal symptoms can indicate airway compromise, necessitating prompt diagnosis and treatment.
- Early intervention for laryngeal lymphoma relapse is generally effective.