Dose-time fractionation study in patients with mycosis fungoides and lymphoma cutis

Single and multiple dose-time fractionation schemes were investigated in patients with mycosis fungoides and lymphoma cutis. The single dose response shows that the disease-free interval is dose dependent. Remission rates are similar when the same total dose is given in either single treatments or multiple daily fractions. Weekly dose fractionation schemes are superior to daily regimes for lymphoma cutis. Changes in tumor volume reduction following single doses to lymphoma cutis indicate that the mean lethal dose (DO) is 90 rads and the extrapolation number (N) is less than 2. These findings are discussed in relation to the reoxygenation process and the cell cycle distribution of the tumor cell population.