[Resistance and resistances]
1Centre Oscar-Lambret, Lille, France.
Bulletin Du Cancer
|December 1, 1994
Abstract:
Drug resistance is a frequent clinical event, induced by more than one mechanism. It is intrinsic and/or acquired by tumoral cell population. But the failure of chemotherapy is also associated to intratumoral drug incorporation and altered drug and/or cell metabolism. Prevention of drug resistance needs integration of pharmacokinetic, biochemical and pathological characteristics of tumoral cell population.
Insights
Drug resistance is a common challenge in cancer treatment, stemming from multiple mechanisms within tumor cells. Overcoming chemotherapy failure requires understanding drug incorporation and metabolism, alongside cellular characteristics.
Area of Science:
- Oncology
- Pharmacology
- Cell Biology
Context:
- Drug resistance is a frequent clinical challenge in cancer therapy.
- Tumor cells exhibit intrinsic or acquired resistance mechanisms.
- Chemotherapy failure is linked to drug incorporation and altered cellular metabolism.
Purpose:
- To explore the multifaceted nature of drug resistance in tumoral cell populations.
- To highlight the contributing factors to chemotherapy failure.
- To emphasize the need for an integrated approach to prevent drug resistance.
Summary:
- Drug resistance in cancer is multifactorial, involving intrinsic and acquired mechanisms.
- Tumor cell populations develop resistance through various pathways.
- Chemotherapy failure is associated with intratumoral drug disposition and metabolic alterations.
Impact:
- Understanding these mechanisms is crucial for developing strategies to overcome drug resistance.
- Integrating pharmacokinetic, biochemical, and pathological data can improve treatment efficacy.
- This knowledge aids in the prevention of treatment failure and enhances patient outcomes.
Related Concept Videos
01:19Resistance
6.1K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K
01:19Ohm's Law
2.5K
Resistors are fundamental components in electrical circuits, often manufactured from metallic alloys or carbon compounds. They model a material's ability to resist the flow of electric current, a characteristic that is crucial in controlling and regulating electrical power within a circuit.
This current-resisting behavior of resistors is governed by Ohm's law, which states that the voltage across a resistor is directly proportional to the current flowing through it.
This current-resisting behavior of resistors is governed by Ohm's law, which states that the voltage across a resistor is directly proportional to the current flowing through it.
2.5K
01:21Ohm's Law
8.0K
Many materials exhibit a simple relationship between the values of current, voltage, and resistance, known as Ohm’s law. The current that flows through most substances is directly proportional to the voltage applied to them. The German physicist Georg Simon Ohm (1787–1854) was the first to demonstrate experimentally that the current in a metal wire is directly proportional to the voltage applied. Any material, component, or device that obeys Ohm’s law, where the current...
8.0K
01:23Resistors In Parallel
6.5K
Resistors are in parallel when one end of all the resistors are connected to a continuous wire of negligible resistance and the other end of all the resistors are also connected to one another through a continuous wire of negligible resistance. In the case of a parallel configuration, the potential drop across each resistor is the same. Current through each resistor can be found using Ohm’s law, I = V/R, where the voltage is constant across each resistor. The sum of the individual currents...
6.5K
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:10Resistors In Series
6.8K
A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination.
In a series circuit, the...
In a series circuit, the...
6.8K