[Systemic methotrexate therapy of persistent trophoblast after tube saving surgery for extrauterine pregnancy]

Is single-drug methotrexate therapy for persistent trophoblastic tissue after conservative laparoscopic surgery an effective medical treatment? Here we report and discuss a case of apparent persistent trophoblastic tissue after salpingotomy and removal of an ectopic pregnancy treated with methotrexate and review the published cases. Single drug-therapy with methotrexate is an alternate approach to a persistent trophoblast after conservative surgery for ectopic pregnancy. Having recently undergone surgery, these women suffer when operated again due to anesthesiologic, surgical and psychological stress. The current case and the published data demonstrate that methotrexate is a simple, efficacious, successful and by now established therapy.