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Influence of the olfactory organ on brain development
1Department of Biological Science, Florida State University, Tallahassee 32306-4075, USA.
Perspectives on Developmental Neurobiology
|January 1, 1994
Summary
The olfactory epithelium continuously renews neurons and aids forebrain development. This sensory organ influences brain formation through cell migration and organizing factors, crucial for survival.
Area of Science:
- Neuroscience
- Developmental Biology
- Sensory Biology
Background:
- The olfactory epithelium is a unique sensory structure capable of lifelong receptor neuron renewal.
- It functions as a neurogenic matrix, generating diverse cell populations during development and adulthood.
Purpose of the Study:
- To discuss molecules involved in olfactory receptor neuron migration and reconnection.
- To explore the olfactory organ's influence on forebrain development, including potential morphogenetic and inducing effects.
Main Methods:
- Review of molecular mechanisms for cell migration and neural reconnection.
- Analysis of experimental data from olfactory placode removal/transplants in amphibians.
Main Results:
- Olfactory placode manipulation in amphibians suggests a significant influence on telencephalon development.
- The olfactory organ's contribution to brain formation via migrating cell populations is highlighted.
Conclusions:
- The olfactory organ exerts a profound morphogenetic and potentially inducing effect on forebrain development.
- This influence, mediated by organizing factors, underscores the olfactory organ's critical role in vertebrate survival.