Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pentoxifylline improves the tissue oxygen extraction capabilities during endotoxic shock

H Zhang1, H Spapen, M Benlabed

  • 1Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.

Shock (Augusta, Ga.)
|August 1, 1994
PubMed
Summary

Pentoxifylline (PTX) improves cellular oxygen availability during endotoxin challenge by enhancing oxygen delivery and tissue extraction. This xanthine derivative treatment attenuated vasoconstriction and improved oxygen consumption in a canine model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental comparison of DSB and CS-DSB mmW formats over a hybrid fiber and FSO fronthaul network for 5G.

Optics express·2021
Same author

Dirofilariasis in Vietnam: A case report and brief review.

Tropical biomedicine·2021
Same author

MECCIAS trial: Metabolic consequences of continuous veno-venous hemofiltration on indirect calorimetry.

Clinical nutrition (Edinburgh, Scotland)·2020
Same author

Energy expenditure and caloric targets during continuous renal replacement therapy under regional citrate anticoagulation. A viewpoint.

Clinical nutrition (Edinburgh, Scotland)·2019
Same author

Elderly versus nonelderly patients with invasive aspergillosis in the ICU: a comparison and risk factor analysis for mortality from the AspICU cohort.

Medical mycology·2017
Same author

Measuring resting energy expenditure during extracorporeal membrane oxygenation: preliminary clinical experience with a proposed theoretical model.

Acta anaesthesiologica Scandinavica·2015

Area of Science:

  • Physiology
  • Pharmacology

Background:

  • Sepsis is a life-threatening condition characterized by dysregulated host response to infection.
  • Pentoxifylline (PTX), a xanthine derivative, has demonstrated protective effects in various sepsis models.
  • The precise mechanisms by which PTX influences oxygen availability in sepsis remain under investigation.

Purpose of the Study:

  • To investigate the effects of Pentoxifylline (PTX) on cellular oxygen availability following endotoxin challenge.
  • To determine if PTX improves oxygen delivery (DO2) and/or tissue oxygen extraction during reduced blood flow.

Main Methods:

  • Anesthetized dogs received an endotoxin challenge followed by induced cardiac tamponade to reduce blood flow.
  • One group was pretreated with PTX, while a control group received no PTX.

Related Experiment Videos

  • Measurements included cardiac index, DO2, oxygen consumption (VO2), ventilation/perfusion matching, and critical DO2.

    • Main Results:

    • PTX significantly attenuated systemic and pulmonary vasoconstriction compared to controls.
    • PTX treatment resulted in increased cardiac index, DO2, and VO2.
    • PTX improved lung ventilation/perfusion matching and enhanced oxygen extraction capacity during cardiac tamponade.

    Conclusions:

    • Pentoxifylline effectively improves oxygen delivery and utilization in a model of endotoxin-induced circulatory stress.
    • PTX demonstrates potential therapeutic benefits in managing oxygen availability during sepsis-related complications.
    • The findings suggest PTX enhances the body's ability to extract oxygen under critical conditions.