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Stoichiometry of fluoride release from fluorhydroxyapatite during acid dissolution
E I Pearce1, N Guha-Chowdhury, Y Iwami
1Dental Research Unit, Health Research Council of NZ, Wellington.
Caries Research
|January 1, 1995
Summary
Fluorhydroxyapatite (FHAp) acts as a fluoride (F) reservoir. High-F FHAp minerals are best for plaque F retention, as F release is controlled during acid dissolution.
Area of Science:
- Biomineralization
- Dental Materials Science
- Fluoride Chemistry
Background:
- Fluorhydroxyapatite (FHAp) is investigated for its potential as a fluoride (F) reservoir in dental plaque.
- Understanding F release from FHAp under acidic conditions is crucial for evaluating its efficacy.
Purpose of the Study:
- To study the release of fluoride (F) from fluorhydroxyapatite (FHAp) during acid dissolution.
- To validate the use of FHAp as an apatitic plaque reservoir for fluoride.
Main Methods:
- Synthesized FHAp minerals with varying F concentrations via aqueous precipitation.
- Exposed synthesized FHAp samples to lactic acid or mixed acid solutions (pH 4.5) until complete dissolution.
- Monitored calcium (Ca), phosphorus (P), and fluoride (F) concentrations in the dissolution solutions.
Main Results:
- The Ca/P ratio in solution remained constant and near the solid's ratio during dissolution.
- The F/Ca ratio in solution changed, initially lower than the solid's ratio, then increasing to a plateau.
- This increase in the F/Ca ratio was more pronounced in low-F FHAp, suggesting F-enriched FHAp precipitation.
Conclusions:
- Fluorhydroxyapatite (FHAp) exhibits controlled fluoride release during acid dissolution.
- High-fluoride FHAp is most effective for use as an apatitic plaque reservoir.
- The findings support the development of FHAp-based materials for enhanced fluoride delivery in plaque.