Related Experiment Video
Updated: Jul 31, 2026

Multi-enzyme Screening Using a High-throughput Genetic Enzyme Screening System
Published on: August 8, 2016
Advances in genosensor research
K L Beattie1, W G Beattie, L Meng
1DNA Technology Laboratory, Houston Advanced Research Center, Woodlands, TX 77381, USA.
Abstract:
Microfabricated devices containing arrays of nucleic acid hybridization sites, known as genosensors, are being developed for a variety of uses in genomic analysis. A great deal of the overall genosensor development effort involves optimization of experimental conditions in the actual use of genosensors. Here we describe a "low-tech" form of genosensor technology, involving arrays of oligonucleotides on glass microscope slides, which can be used to define optimal operating conditions and to develop applications of hybridization arrays in genome mapping and sequencing. In addition, we describe a porous silicon genosensor, which can be operated in a flowthrough mode, and discuss its advantages over current flat-surface designs. Porous silicon genosensors containing arrays of DNA fragments offer several unique capabilities in genome analysis.
Related Concept Videos
Genomics
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Reporter Genes
Commonly used reporter...
Pharmacogenomics: Identification of New Drug Targets
Modern Molecular Taxonomy
Microbial Biosensors

