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Ketotifen and nitroxides decrease capsaicin-augmented ethanol-induced gastric damage in rats

F Karmeli1, R Eliakim, E Okon

  • 1Department of Medicine, Hadassah University Hospital-Mount Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Digestive Diseases and Sciences
|May 1, 1995
PubMed
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Capsaicin worsens ethanol-induced gastric injury by activating C-fibers. Mast cell stabilizers and antioxidants like Tempol protect against this amplified damage, suggesting therapeutic potential for gastric protection.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Toxicology

Background:

  • Systemic capsaicin administration is known to exacerbate ethanol-induced gastric mucosal injury.
  • Primary afferent C-fibers play a role in mediating this amplified damage.

Purpose of the Study:

  • To investigate the effect of capsaicin on gastric mucosa and inflammatory mediators in rats treated with saline or ethanol.
  • To evaluate the protective mechanisms against capsaicin-potentiated ethanol-induced gastric injury.

Main Methods:

  • Rats were treated with capsaicin (subcutaneous) to ablate C-fibers, followed by ethanol administration.
  • Gastric mucosal injury was assessed, and the effects of ketotifen (mast cell stabilizer) and Tempol (antioxidant) were evaluated.
  • Levels of leukotriene B4 and C4 were measured.

Related Experiment Videos

Main Results:

  • Capsaicin administration tripled ethanol-induced gastric damage.
  • Ketotifen offered partial protection against the amplified injury.
  • Tempol completely prevented the enhanced ulceration and significantly reduced leukotriene generation.

Conclusions:

  • Mast cells and free radicals contribute significantly to amplified gastric injury induced by capsaicin and ethanol.
  • Pharmacological interventions targeting mast cell degranulation and free radical scavenging show therapeutic promise for preventing gastric injury.