Related Experiment Videos
A Drosophila E(spł) gene is "neurogenic" in Xenopus: a green fluorescent protein study
D Tannahill1, S Bray, W A Harris
1Department of Anatomy, University of Cambridge, England.
Developmental Biology
|April 1, 1995
Abstract:
A Drosophila Enhancer of split [E(spl)] bHLH protein, m delta, was misexpressed in Xenopus embryos along with green fluorescent protein (GFP) as a lineage label. The Drosophila protein translocated to the nucleus of Xenopus cells and led to neural hypertrophy in the GFP-labeled dorsal ectoderm, a phenotype similar to that caused by the misexpression of activated Xotch. Our data indicate a strong conservation in E(spl)bHLH function in the Notch signaling pathway of flies and vertebrates.