Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preventing non-insulin-dependent diabetes

W C Knowler1, K M Narayan, R L Hanson

  • 1National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.

Diabetes
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of complementary food introduction and age at diagnosis of type 1 diabetes: the SEARCH nutrition ancillary study (SNAS).

European journal of clinical nutrition·2014
Same author

Comparison of two waist circumference measurement protocols: the SEARCH for diabetes in youth study.

Pediatric obesity·2012
Same author

Efficacy, safety and lack of immunogenicity of insulin aspart compared with regular human insulin for women with gestational diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·2007
Same author

Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia.

Diabetologia·2006
Same author

The combination oral and nutritional treatment of late-onset diabetes mellitus (CONTROL DM) trial results.

Diabetic medicine : a journal of the British Diabetic Association·2004
Same author

Increasing body mass index at diagnosis of diabetes in young adult people during 1983-1999 in the Diabetes Incidence Study in Sweden (DISS).

Journal of internal medicine·2003
Same journal

Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.

Diabetes·2026
Same journal

Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.

Diabetes·2026
Same journal

Targeting the ADA/ADO Axis Rescues β-Cell Failure in Type 2 Diabetes.

Diabetes·2026
Same journal

TXNIP Is Positioned as a Key Mediator of Hyperglycemia-Induced Vascular Senescence.

Diabetes·2026
Same journal

Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience.

Diabetes·2026
Same journal

The Mechanism of TNF-α Combined With High Glucose in Regulating Calnexin Aggravates Endoplasmic Reticulum Stress in Endothelial Cell Injury of Diabetic Retinopathy.

Diabetes·2026
See all related articles

Non-insulin-dependent diabetes mellitus (NIDDM) may be preventable by modifying risk factors like obesity and diet. Further research is needed to confirm the effectiveness of interventions in preventing NIDDM.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Preventive Medicine

Background:

  • Non-insulin-dependent diabetes mellitus (NIDDM) is linked to modifiable risk factors including obesity, sedentary lifestyle, and high-fat diets.
  • Metabolic precursors to NIDDM, such as insulin resistance and impaired glucose tolerance, show potential for improvement through lifestyle changes and pharmacological interventions.
  • These factors suggest that NIDDM might be preventable to a certain degree.

Purpose of the Study:

  • To evaluate the hypothesis that NIDDM can be prevented.
  • To assess the efficacy of interventions such as dietary modification, increased physical activity, and drug treatment in NIDDM prevention.

Main Methods:

  • Review of several small clinical trials investigating NIDDM prevention strategies.

Related Experiment Videos

  • Analysis of studies employing dietary changes, physical activity, and drug treatments as preventive measures.

    • Main Results:

    • Some existing studies indicate a potential preventive effect of interventions on NIDDM development.
    • However, conclusions drawn from these studies are constrained by limitations in sample size, randomization methods, and intervention intensity.
    • The overall evidence supporting NIDDM prevention requires further robust investigation.

    Conclusions:

    • While NIDDM risk factors are modifiable and some metabolic abnormalities are reversible, definitive proof of NIDDM prevention is lacking.
    • The hypothesis that NIDDM is preventable warrants further rigorous testing through larger, well-designed clinical trials.
    • More research is essential to establish effective strategies for preventing non-insulin-dependent diabetes mellitus.