Intestinal motility and jejunal feeding in children with chronic intestinal pseudo-obstruction
View abstract on PubMed
Summary
This summary is machine-generated.Successful jejunal feeding in children with chronic intestinal pseudo-obstruction (CIP) is linked to the presence of migrating motor complexes (MMCs). This finding offers an alternative to parenteral nutrition for these patients.
Area Of Science
- Pediatric Gastroenterology
- Gastrointestinal Motility Disorders
- Surgical Nutrition
Background
- Chronic intestinal pseudo-obstruction (CIP) in children often necessitates total parenteral nutrition (TPN), which is associated with significant morbidity and mortality.
- Gastrostomy feeding can be insufficient for some children with CIP, leading to failure to thrive.
Purpose Of The Study
- To identify manometric patterns predictive of successful jejunal feeding in pediatric patients with CIP.
- To evaluate jejunal feeding as an alternative to TPN in children with CIP.
Main Methods
- Antroduodenal and jejunal manometry were performed in 18 children (age 1-9 years) with CIP.
- Patients underwent jejunostomy placement and initiated continuous drip jejunal feeding with an elemental formula.
- Follow-up duration averaged 1.6 years.
Main Results
- Jejunal feeding successfully weaned 9 patients with migrating motor complexes (MMCs) off TPN.
- Three of nine patients without MMCs also benefited from jejunal feeding (P < 0.01).
- Antroduodenal and jejunal manometry showed similar findings in 77.7% of patients, and qualitative abnormalities in 55%.
Conclusions
- Jejunal tube feeding is a viable alternative to TPN for selected children with CIP who have failed gastrostomy feeding.
- The presence of MMCs on manometry is a significant predictor of successful adaptation to jejunal feeding.