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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

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Intestinal motility and jejunal feeding in children with chronic intestinal pseudo-obstruction

C Di Lorenzo1, A F Flores, T Buie

  • 1Department of Pediatrics, Harbor-UCLA Medical Center, USA.

Gastroenterology
|May 1, 1995
PubMed

Insights

Successful jejunal feeding in children with chronic intestinal pseudo-obstruction (CIP) is linked to the presence of migrating motor complexes (MMCs). This finding offers an alternative to parenteral nutrition for these patients.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders
  • Surgical Nutrition

Background:

  • Chronic intestinal pseudo-obstruction (CIP) in children often necessitates total parenteral nutrition (TPN), which is associated with significant morbidity and mortality.
  • Gastrostomy feeding can be insufficient for some children with CIP, leading to failure to thrive.

Purpose of the Study:

  • To identify manometric patterns predictive of successful jejunal feeding in pediatric patients with CIP.
  • To evaluate jejunal feeding as an alternative to TPN in children with CIP.

Main Methods:

  • Antroduodenal and jejunal manometry were performed in 18 children (age 1-9 years) with CIP.
  • Patients underwent jejunostomy placement and initiated continuous drip jejunal feeding with an elemental formula.
  • Follow-up duration averaged 1.6 years.

Main Results:

  • Jejunal feeding successfully weaned 9 patients with migrating motor complexes (MMCs) off TPN.
  • Three of nine patients without MMCs also benefited from jejunal feeding (P < 0.01).
  • Antroduodenal and jejunal manometry showed similar findings in 77.7% of patients, and qualitative abnormalities in 55%.

Conclusions:

  • Jejunal tube feeding is a viable alternative to TPN for selected children with CIP who have failed gastrostomy feeding.
  • The presence of MMCs on manometry is a significant predictor of successful adaptation to jejunal feeding.
Abstract

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