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A comparison of the accumulation of novobiocin into bacteria with its antibacterial properties
K Barrett-Bee1, P Pinder, J Stawpert
1Infection Research Department, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK.
The Journal of Antimicrobial Chemotherapy
|December 1, 1994
Abstract:
The accumulation of novobiocin in bacteria has been compared with the MIC, inhibition of DNA biosynthesis and inhibition of the activity of isolated DNA gyrase for a range of species. There was a good correlation between MIC and the inhibition of DNA biosynthesis and DNA gyrase. Novobiocin accumulation did not correlate with any other parameter.
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