Volume-activated chloride currents associated with the multidrug resistance P-glycoprotein

The ability to regulate volume is an important property of most, if not all cells. In epithelial cells, amongst others, cell volume-activated chloride channels are central to this response. The molecular identities of these channels are not yet known. Expression of the human multidrug resistance P-glycoprotein (P-gp) has been associated with cell volume-regulated chloride currents, although the nature of this association is the subject of debate. Recent data indicate that P-gp acts by regulating the activation of an endogenous channel protein. In this review, evidence associating P-gp with cell volume-activated chloride currents, and the possible mechanisms by which this might be achieved, are discussed.