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Propafenone-induced peripheral neuropathy

P J Galasso1, M S Stanton, H Vogel

  • 1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.

Mayo Clinic Proceedings
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

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Propafenone, an antiarrhythmic drug, may cause peripheral neuropathy. A patient developed small fiber neuropathy symptoms, which resolved after discontinuing propafenone hydrochloride.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Propafenone hydrochloride is a Class IC antiarrhythmic agent used for ventricular and supraventricular arrhythmias.
  • Peripheral neuropathy is a potential adverse effect of various medications.

Observation:

  • A patient presented with symptoms of peripheral neuropathy, including pain and hyperesthesia in extremities.
  • The patient had been taking propafenone hydrochloride for one year to manage ventricular arrhythmias.

Findings:

  • Nerve conduction velocity tests and sural nerve biopsy revealed distal small fiber neuropathy.
  • Thermoregulatory sweat tests and autonomic function tests were abnormal, consistent with neuropathy.

Implications:

  • This case suggests a potential link between propafenone hydrochloride and the development of peripheral neuropathy.

Related Experiment Videos

  • Discontinuation of propafenone led to the resolution of neuropathy symptoms, indicating a possible drug-induced etiology.