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Related Experiment Videos

Calbindin-D28K localization in the primate inner ear

S Usami1, H Shinkawa, Y Inoue

  • 1Department of Otorhinolaryngology, Hirosaki University School of Medicine, Japan.

ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
|March 1, 1995
PubMed
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Calbindin-D28K (CB-D28K), a calcium-binding protein, is present in the inner ear of humans and squirrel monkeys. This protein is found in hair cells, neurons, and fibrocytes, suggesting roles in neurotransmission and calcium regulation.

Area of Science:

  • Neuroscience
  • Otolaryngology
  • Cell Biology

Background:

  • Calcium-binding proteins play crucial roles in cellular functions.
  • Calbindin-D28K (CB-D28K) is implicated in calcium homeostasis.
  • The distribution of CB-D28K in the primate inner ear is not fully understood.

Purpose of the Study:

  • To investigate the distribution of calbindin-D28K (CB-D28K) in the adult human and squirrel monkey inner ear.
  • To elucidate the potential roles of CB-D28K in auditory and vestibular sensory organs.
  • To explore non-neuronal localizations of CB-D28K in the squirrel monkey inner ear.

Main Methods:

  • Immunocytochemical methods were employed to detect CB-D28K.
  • The study examined tissue from adult humans and squirrel monkeys.

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  • Analysis focused on the organ of Corti, vestibular hair cells, spiral ganglion, and vestibular end organs.

    • Main Results:

    • CB-D28K immunoreactivity was observed in inner and outer hair cells, vestibular hair cells, and spiral and vestibular ganglion cells in both species.
    • Non-neuronal CB-D28K localization was identified in fibrocytes of the spiral ligament and vestibular end organs in squirrel monkeys.
    • CB-D28K particles were abundant in the otoconial membrane of the maculae.

    Conclusions:

    • CB-D28K is localized in afferent neuronal components of the primate auditory and vestibular systems, potentially regulating calcium for neurotransmission.
    • Fibrocytes in the squirrel monkey inner ear contain CB-D28K, suggesting a role in regulating perilymphatic fluid calcium.
    • CB-D28K may be involved in the formation of otoconia in the maculae.