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Related Experiment Videos

Proteus species isolated from human eyes

M Okumoto, G Smolin, R Belfort

    American Journal of Ophthalmology
    |April 1, 1976
    PubMed
    Summary

    Gentamicin effectively controlled Proteus eye infections, including Proteus mirabilis and Proteus morganii. Both in vitro and in vivo studies confirmed gentamicin

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    Area of Science:

    • Ophthalmology
    • Microbiology
    • Infectious Diseases

    Background:

    • Proteus species are opportunistic pathogens that can cause serious eye infections.
    • Understanding the prevalence and antibiotic susceptibility of Proteus in ocular infections is crucial for effective treatment.

    Purpose of the Study:

    • To identify the species of Proteus isolated from human eye infections.
    • To evaluate the in vitro and in vivo efficacy of antibiotics, particularly gentamicin, against these isolates.

    Main Methods:

    • Isolation and identification of Proteus species from human ocular samples.
    • In vitro antibiotic sensitivity testing of Proteus isolates.
    • In vivo efficacy study using experimental Proteus keratitis in rabbits treated with gentamicin and tobramycin.

    Main Results:

    • Proteus mirabilis (85%) and Proteus morganii (15%) were the predominant species isolated.
    • Gentamicin demonstrated superior in vitro activity against both P. mirabilis and P. morganii compared to other tested antibiotics.
    • In vivo, gentamicin and tobramycin showed comparable clinical outcomes in rabbit keratitis, but gentamicin was more effective in microbial eradication.

    Conclusions:

    • Proteus mirabilis and Proteus morganii are significant causes of bacterial keratitis.
    • Gentamicin is a highly effective antibiotic for treating Proteus ocular infections, offering superior eradication potential in vivo.

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