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Related Experiment Videos

Adenosine-sensitive atrial tachycardia

J G Kall1, D Kopp, B Olshansky

  • 1Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.

Pacing and Clinical Electrophysiology : PACE
|February 1, 1995
PubMed
Summary
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Adenosine can terminate atrial tachycardia in a significant number of patients, especially those with beta-adrenergic stimulation. This suggests adenosine-sensitive atrial tachycardia may be more common than previously thought.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Limited data exist on adenosine's effect on atrial tachycardia.
  • Adenosine is a common pharmacologic stress agent.

Purpose of the Study:

  • To investigate the effect of adenosine on sustained atrial tachycardia.
  • To identify predictors of adenosine sensitivity in atrial tachycardia.

Main Methods:

  • Adenosine (6-12 mg) was administered to 17 patients with sustained atrial tachycardia.
  • Electrophysiological studies were performed to exclude other supraventricular tachycardia mechanisms.
  • Patients with spontaneous or induced tachycardias were analyzed for adenosine response.

Main Results:

  • Adenosine terminated atrial tachycardia in 18% of patients and suppressed it in 23%.

Related Experiment Videos

  • Adenosine sensitivity was observed in 4 of 9 patients with spontaneous tachycardias, particularly those facilitated by isoproterenol.
  • Isoproterenol facilitation of tachycardia predicted adenosine sensitivity (P=0.02).

    • Conclusions:

    • Adenosine-sensitive atrial tachycardia may be more common than previously recognized.
    • Adenosine sensitivity is not specific to tachycardia mechanism and is not predicted by pacing response.
    • Atrial tachycardias dependent on beta-adrenergic stimulation are most likely to be terminated by adenosine.