Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Validation of a dose-point kernel convolution technique for internal dosimetry

H B Giap1, D J Macey, J E Bayouth

  • 1Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston 77030.

Physics in Medicine and Biology
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Handcrafted firearm suicide: About the unusual use of a mole gun.

Legal medicine (Tokyo, Japan)·2022
Same author

Buccal glands of adults of the lamprey Mordacia mordax, including comparisons with other species.

Journal of morphology·2018
Same author

The junction zone: Initial site of mineralization in radula teeth of the chiton Cryptoplax striata (Mollusca: Polyplacophora).

Journal of morphology·2018
Same author

Oxygen consumption and responses to hypoxia of ammocoetes of the southern hemisphere lampreyGeotria australis.

Fish physiology and biochemistry·2013
Same author

Seasonal and estradiol-17β-stimulated changes in thyroid function of adult Geotria australis, a southern hemisphere lamprey.

Fish physiology and biochemistry·2013
Same author

An increase in the concentration of hepatic iron during the metamorphosis of the lamprey Geotria australis is accompanied by increased superoxide dismutase activity.

Fish physiology and biochemistry·2013
Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026
Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026
Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026
Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
See all related articles

This study validates a 3D dose-point kernel convolution technique for calculating absorbed dose distributions from 131I. The method accurately predicts radiation dose, showing a mean difference of -1% compared to measurements.

Area of Science:

  • Medical Physics
  • Nuclear Medicine
  • Radiotherapy Dosimetry

Background:

  • Accurate three-dimensional (3D) absorbed dose calculation is crucial for radionuclide therapy.
  • Quantitative single-photon-emission computed tomography (SPECT) provides 3D activity distributions.
  • Existing methods require validation for clinical application.

Purpose of the Study:

  • To validate a dose-point kernel convolution technique for 3D absorbed dose distribution of Iodine-131 (131I).
  • To assess the accuracy of the technique by comparing calculated doses with experimental measurements.
  • To compare the technique with established dosimetry formalisms.

Main Methods:

  • Calculated a dose-point kernel for penetrating radiations using Monte Carlo simulation.

Related Experiment Videos

  • Convolved the kernel with 3D 131I activity maps from quantitative SPECT using fast Fourier transform (FFT).
  • Validated calculations against thermoluminescent dosimeter (TLD) measurements and MIRD formalism in a phantom study.

    • Main Results:

    • The convolution technique achieved a mean percentage difference of -1% (SD 3.6%) compared to TLD measurements.
    • The method demonstrated agreement within 15% with the MIRD formalism for phantom dosimetry.
    • The 3D FFT convolution calculation was efficient, completing in under 40 seconds on a personal computer.

    Conclusions:

    • The validated dose-point kernel convolution technique accurately determines 3D absorbed dose distributions from 131I.
    • This method offers a computationally efficient and reliable tool for internal dosimetry in nuclear medicine.
    • The technique shows promise for improving treatment planning and dose assessment in radionuclide therapies.