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Eosinophilic gastroenteritis presenting as protein--losing enteropathy (case report)
S Karademir1, A Akçayöz, K Bek
1Dr. Sami Ulus Children's Hospital, Ankara, Turkey.
The Turkish Journal of Pediatrics
|January 1, 1995
Summary
Eosinophilic gastroenteritis in children, an uncommon condition, involves intestinal inflammation. This case study shows successful treatment with prednisolone, resolving symptoms and reducing immunoglobulin E levels.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Gastrointestinal Diseases
Background:
- Eosinophilic gastroenteropathy is a rare, idiopathic pediatric disorder characterized by eosinophilic inflammation of the gastrointestinal tract.
- Mucosal involvement often leads to diarrhea and potential malabsorption of proteins and fats.
Observation:
- A seven-year-old female presented with abdominal pain, diarrhea, and edema, diagnosed with eosinophilic gastroenteritis via endoscopic biopsies.
- Despite lacking peripheral eosinophilia, the patient exhibited elevated serum immunoglobulin E (1590 mg/dl).
- Radiological findings included mucosal thickening and prominent folds in the stomach, small intestine, and colon.
Findings:
- Endoscopic biopsies confirmed eosinophilic gastroenteritis.
- Treatment with prednisolone (2 mg/kg/day) led to symptom resolution and a significant decrease in serum immunoglobulin E to 500 mg/dl within 45 days.
- The patient remains relapse-free on a low maintenance dose of prednisolone.
Implications:
- This case highlights the effectiveness of prednisolone in managing pediatric eosinophilic gastroenteritis, even in the absence of peripheral eosinophilia.
- Early diagnosis and prompt treatment are crucial for favorable outcomes in this condition.
- Further research into the specific triggers and long-term management of eosinophilic gastroenteritis is warranted.