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Autonomic dysfunction in Alzheimer's disease

A Algotsson1, M Viitanen, B Winblad

  • 1Department of Geriatrics, Huddinge University Hospital, Sweden.

Acta Neurologica Scandinavica
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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Alzheimer's disease patients exhibit autonomic dysfunction, impacting both parasympathetic and sympathetic nervous system functions. This study assessed these autonomic functions in patients compared to healthy individuals.

Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Autonomic nervous system (ANS) dysfunction is increasingly recognized in neurodegenerative conditions.

Purpose of the Study:

  • To investigate autonomic functions in patients with Alzheimer's disease.
  • To compare parasympathetic and sympathetic functions between AD patients and healthy controls.

Main Methods:

  • Twenty-nine patients meeting NINCDS-ADRDA criteria for Alzheimer's disease were enrolled.
  • A range of tests were performed to assess parasympathetic and sympathetic nervous system functions.
  • Eighteen patients underwent repeat testing after one year.
  • Fifteen healthy subjects without a family history of dementia served as controls.

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Main Results:

  • Alzheimer's disease patients demonstrated significant signs of autonomic dysfunction compared to healthy controls.
  • Dysfunction was observed in both parasympathetic and vasomotor sympathetic functions.
  • Longitudinal data from eighteen patients indicated persistent autonomic impairment over one year.

Conclusions:

  • Autonomic dysfunction is a notable feature in Alzheimer's disease.
  • Both parasympathetic and sympathetic branches of the autonomic nervous system are affected.
  • These findings suggest potential therapeutic targets within the autonomic nervous system for AD management.